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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN5 All Species: 20.91
Human Site: Y353 Identified Species: 57.5
UniProt: P54829 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54829 NP_001035059.1 565 63512 Y353 P D D P L S S Y I N A N Y I R
Chimpanzee Pan troglodytes XP_509221 657 73878 Y446 V T D S L S T Y I N A N Y I R
Rhesus Macaque Macaca mulatta XP_001096604 784 87594 Y572 P D D P L S S Y I N A N Y I R
Dog Lupus familis XP_542528 578 64634 Y366 P D D P L S S Y I N A N Y I R
Cat Felis silvestris
Mouse Mus musculus P54830 541 60797 Y329 P E D P L S S Y I N A N Y I R
Rat Rattus norvegicus P35234 369 42348 G178 K V Y I A T Q G P I V S T V V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512315 769 86755 Y558 A T D A L S T Y I N A N Y I R
Chicken Gallus gallus XP_421017 525 60118 A331 G E E K V Y I A T Q G P I V N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_687962 521 58630 I326 G G K E K A Y I A T Q G P T V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 38.2 70 87.1 N.A. 86 61.9 N.A. 36.6 66.5 N.A. 55.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 54.1 70.9 89.9 N.A. 89.5 63.3 N.A. 49.1 75.9 N.A. 66.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 73.3 100 100 N.A. 93.3 0 N.A. 73.3 0 N.A. 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 80 100 100 N.A. 100 20 N.A. 80 26.6 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 12 12 12 0 12 12 0 67 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 34 67 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 23 12 12 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 23 12 0 0 0 0 0 12 0 0 12 12 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 12 0 0 12 12 67 12 0 0 12 67 0 % I
% Lys: 12 0 12 12 12 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 67 0 67 0 0 12 % N
% Pro: 45 0 0 45 0 0 0 0 12 0 0 12 12 0 0 % P
% Gln: 0 0 0 0 0 0 12 0 0 12 12 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 67 % R
% Ser: 0 0 0 12 0 67 45 0 0 0 0 12 0 0 0 % S
% Thr: 0 23 0 0 0 12 23 0 12 12 0 0 12 12 0 % T
% Val: 12 12 0 0 12 0 0 0 0 0 12 0 0 23 23 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 12 0 0 12 12 67 0 0 0 0 67 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _